DNA primase is a DNA-dependent RNA polymerase that synthesizes the first ~10 nucleotides and then transfers the substrate to polymerase α to complete primer ...
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Feb 4, 2015 · DNA primase catalyzes de novo synthesis of a short RNA primer that is further extended by replicative DNA polymerases during initiation of ...
Sep 6, 2021 · Iron–sulfur (Fe/S) clusters (ISCs) are redox-active protein cofactors that their synthesis, transfer, and insertion into target proteins ...
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Oct 19, 2022 · Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase. Nucl. Acids Res. 47, 5712–5722 (2019) ...
A novel hypothesis for iron–sulfur cluster function has recently been proposed on the basis of electrochemical and biophysical data showing that the cluster in ...
Abstract. DNA primase catalyzes de novo synthesis of a short RNA primer that is further extended by replicative DNA polymerases during initiation of DNA ...
Besides electron transfer and storage roles, Fe–S clusters can function in many diverse roles including structural, substrate binding and activation, regulation ...
(1) published evidence that the Fe-S cluster of the DNA-dependent RNA polymerase known as primase is redox active and that its oxidation enhances DNA binding.
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Aug 8, 2023 · A Fe–S cluster located at this site could modulate the affinity of nsp13 for the paired template- primer RNA through a redox switch mechanism.
Iron–sulfur clusters are important cofactors for proteins involved in metabolism and electron transfer but are also sometimes found in enzymes involved in ...